Vad betyder cin 2 3

The cervical intraepithelial neoplasia (CIN) are abnormal cells are found on the surface of the cervix. Cervical intraepithelial neoplasia is not cancer. Cervical intraepithelial neoplasia are changes to the cells that cover the outside of the cervix (squamous cells).

It is widely accepted that invasive squamous cell carcinoma of the cervix, which is the commonest histological type, fryst vatten preceded bygd a pre-invasive stage of the disease, where the abnormal cells are confined to the epithelium. This stage of non-invasive disease is known as cervical intraepithelial neoplasia (CIN) and is directly related to the processes of infection and integration of human papillomavirus (HPV) as described in the previous chapter.

There are 3 grades of cervical intraepithelial neoplasia and they relate to how deeply the abnormal cells have gone into the skin covering the cervix.

1. Cervical intraepithelial neoplasia grade 1 (CIN 1) or low grade squamous intraepithelial skada (LSIL) – up to one third of the thickness of the lining covering the cervix has abnormal cells.
2. Cervical intraepithelial neoplasia grade 2 (CIN 2) or high-grade squamous
3. 

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Handl&#;ggning efter utredning som visar dysplasi

Rekommendation

• Kvinnor med cervixdysplasi bör rekommenderas att inte röka. (GRADE +++¹⁶)

 ^{16 Observationsstudier och interventionsstudier med stark effekt}

Naturalf&#;rlopp och exspektans

Det finns flera faktorer att ta hänsyn till vid beslut om exspektans eller behandling av dysplasi. Syftet med behandling är att ta bort precancerösa lesioner för att hindra progress till cancer. Men olika dysplastiska lesioner och HPV-typer har olika tendens till progress respektive regress 2ed-cffcefaec9b7dfdcdce6f5fbda8ddcbfea05e-4fb76d-dcd3c3ffacdc9ccafabc Behandling, men även lesionen i sig, kan öka risken för förtidsbörd och sena missfall. Flera riskfaktorer för cervixdysplasi och förtidsbörd är gemensamma varför detta är svårtolkat faacedc-4cae-9edf8bddeceafeb7-ab04ffdfabf-acccaee0-d02bbefc59da2aeaf3d-8bfe48d6b Beslut om aktiv exspektans eller behandling tas av kolposkopisten i samråd med patienten.

En förutsättning för aktiv exspektans är att kvinnan förväntas kunna följa den r

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CIN1 lesions usually subside on their own (in % of cases) within years after the biopsies and diagnosis. This is why the term «intraepithelial neoplasia» is considered an exaggeration. It is believed that this kind of cell atypia is due to simple infection from HPV (infectious atypia). This is why CIN1 lesions are classified as LSIL (low-grade lesions).

On the contrary, CIN2 and CIN3 lesions have a significant possibility of evolving into invasive cancer in the following years. This is why they are classified as HSIL (high-grade lesions). If CIN2/3 or HSIL lesions aren’t treated, there is a future risk of invasive cancer. The risk is estimated at % of all cases, but is lower at younger ages and higher after the age of The risk for carcinogenesis (development of cancer) increases with age.

CIN3 lesions have a higher risk for invasive cancer. Especially in regard to CIN3 and CIS lesions, the lifetime risk is estimated at %. Women older than 30, with CIN3/CIS lesions covering a large part of the cervical surface, are at the highest risk.